abstract：:Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs ...

journal_title：Frontiers in physiology

authors： Groen M,López-Dávila AJ,Zittrich S,Pfitzer G,Stehle R

更新日期：2020-06-03 00:00:00

abstract：:The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse with the constitut...

journal_title：Frontiers in physiology

authors： van der Pijl RJ,Hudson B,Granzier-Nakajima T,Li F,Knottnerus AM,Smith J,Chung CS,Gotthardt M,Granzier HL,Ottenheijm CAC

更新日期：2020-05-29 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are kno...

journal_title：Frontiers in physiology

authors： Fu Z,Gong L,Liu J,Wu J,Barrett EJ,Aylor KW,Liu Z

更新日期：2020-05-29 00:00:00

abstract：:Before they develop competent endothermy, mammals and birds are sensitive to fluctuating temperature. It follows that early life thermal environment can trigger changes to the ontogeny of thermoregulatory control. At the ecological level, we have incomplete knowledge of how such responses affect temperature tolerance ...

journal_title：Frontiers in physiology

authors： Nord A,Giroud S

更新日期：2020-05-25 00:00:00

abstract：:The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression of atherosclerosis, the instigator of ischemic heart disease. Contemporary limitations related to studying this cellular population and senescence-rel...

journal_title：Frontiers in physiology

authors： Stojanović SD,Fuchs M,Kunz M,Xiao K,Just A,Pich A,Bauersachs J,Fiedler J,Sedding D,Thum T

更新日期：2020-05-25 00:00:00

abstract：:Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as positive adhesiotropy, via PKA-mediated phosphorylation of plakoglobin (...

journal_title：Frontiers in physiology

authors： Yeruva S,Kempf E,Egu DT,Flaswinkel H,Kugelmann D,Waschke J

更新日期：2020-05-21 00:00:00

abstract：:Restitution of cutaneous sensory function is accomplished by neural regenerative processes of distinct mechanisms following peripheral nerve lesions. Although methods available for the study of functional cutaneous nerve regeneration are specific and accurate, they are unsuitable for the longitudinal follow-up of the ...

journal_title：Frontiers in physiology

authors： Lakatos S,Jancsó G,Horváth Á,Dobos I,Sántha P

更新日期：2020-05-21 00:00:00

abstract：:Pyrokinins are structurally related insect neuropeptides, characterized by their myotropic, pheromonotropic and melanotropic roles in some insects, but their function is unclear in blood-feeding arthropods. In the present study, we functionally characterized the pyrokinin-1 and pyrokinin-2 receptors (PK1-R and PK2-R, ...

journal_title：Frontiers in physiology

authors： Lajevardi A,Paluzzi JV

更新日期：2020-05-21 00:00:00

abstract：:Ocean acidification (OA) and warming seas are significant concerns for coastal systems and species. The Atlantic longfin squid, Doryteuthis pealeii, a core component of the Northwest Atlantic trophic web, has demonstrated impacts, such as reduced growth and delayed development, under high chronic exposure to acidifica...

journal_title：Frontiers in physiology

authors： Zakroff CJ,Mooney TA

更新日期：2020-05-20 00:00:00

abstract：:The effect of training status on post-exercise flow-mediated dilation (FMD) is not well characterized. We tested the hypothesis that the more trained the subjects, the lower the reduction in FMD after an acute bout of aerobic exercise. Forty-seven men (mean ± SD, age: 20.1 ± 1.2 years, body mass: 75.5 ± 5.1 kg, height...

journal_title：Frontiers in physiology

authors： Kapilevich LV,Kologrivova VV,Zakharova AN,Mourot L

更新日期：2020-05-08 00:00:00

abstract：:Percutaneous edge-to-edge mitral valve (MV) repair using MitraClip has been recently established as a treatment option for patients with heart failure and functional mitral regurgitation (MR), which significantly expands the number of patients that can be treated with this device. This study aimed to quantify the morp...

journal_title：Frontiers in physiology

authors： Caballero A,Mao W,McKay R,Hahn RT,Sun W

更新日期：2020-05-07 00:00:00

abstract：:In addition to its roles in the maintenance of interstitial fluid homeostasis and immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary lipids to the blood circulation. Recent work within the past two decades has identified an important relationship between lymphatic dysfuncti...

journal_title：Frontiers in physiology

authors： Norden PR,Kume T

更新日期：2020-05-05 00:00:00

abstract：:Gut microbiota has been reported to contribute to reduced diet-induced obesity upon cold exposure. Furthermore, gut microbiome fermentation determines the efficacy of exercise for diabetes prevention and enhances exercise performance. However, there have been no systematic examinations of changes in gut microbiome com...

journal_title：Frontiers in physiology

authors： Meng Y,Chen L,Lin W,Wang H,Xu G,Weng X

更新日期：2020-05-04 00:00:00

abstract：:Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects...

journal_title：Frontiers in physiology

authors： Catala A,Youssef LA,Reisz JA,Dzieciatkowska M,Powers NE,Marchetti C,Karafin M,Zimring JC,Hudson KE,Hansen KC,Spitalnik SL,D'Alessandro A

更新日期：2020-04-30 00:00:00

abstract：:In our previous study, we reported a high temperature adapted strain (HTAS) of the predatory mite Neoseiulus barkeri was artificially selected via a long-term heat acclimation (35°C) and frequent heat hardenings. To understand the molecular basis of heat acclimation, 'omics' analyses were performed to compare the diff...

journal_title：Frontiers in physiology

authors： Tian CB,Li YY,Huang J,Chu WQ,Wang ZY,Liu H

更新日期：2020-04-29 00:00:00

abstract：:Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...

journal_title：Frontiers in physiology

authors： Flatt JF,Stevens-Hernandez CJ,Cogan NM,Eggleston DJ,Haines NM,Heesom KJ,Picard V,Thomas C,Bruce LJ

更新日期：2020-04-28 00:00:00

abstract：:Temperature is an important abiotic factor that drives the evolution of ectotherms owing to its pervasive effects at all levels of organization. Although a species' thermal tolerance is environmentally driven within a spatial cline, it may be constrained over time due to differential phylogenetic inheritance. At the l...

journal_title：Frontiers in physiology

authors： Faria SC,Bianchini A,Lauer MM,Zimbardi ALRL,Tapella F,Romero MC,McNamara JC

更新日期：2020-04-24 00:00:00

abstract：:Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder (AUD). However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alter...

journal_title：Frontiers in physiology

authors： Gao B,Emami A,Zhou R,Lang S,Duan Y,Wang Y,Jiang L,Loomba R,Brenner DA,Stärkel P,Schnabl B

更新日期：2020-04-24 00:00:00

abstract：:In our digitized society, advanced information and communication technology and highly interactive work environments impose high demands on cognitive capacity. Optimal workload conditions are important for assuring employee's health and safety of other persons. This is particularly relevant in safety-critical occupati...

journal_title：Frontiers in physiology

authors： Radüntz T,Fürstenau N,Mühlhausen T,Meffert B

更新日期：2020-04-21 00:00:00

abstract：:Several studies have highlighted the interplay between metabolism, immunity and inflammation. Both tissue resident and infiltrating immune cells play a major role in the inflammatory process of rheumatoid arthritis (RA) via the production of cytokines, adipo-cytokines and metabolic intermediates. These functions are m...

journal_title：Frontiers in physiology

authors： Pucino V,Certo M,Varricchi G,Marone G,Ursini F,Rossi FW,De Paulis A,Mauro C,Raza K,Buckley CD

更新日期：2020-04-17 00:00:00

abstract：:The importance of electrolyte concentrations for cardiac function is well established. Electrolyte variations can lead to arrhythmias onset, due to their important role in the action potential (AP) genesis and in maintaining cell homeostasis. However, most of the human AP computer models available in literature were d...

journal_title：Frontiers in physiology

authors： Bartolucci C,Passini E,Hyttinen J,Paci M,Severi S

更新日期：2020-04-15 00:00:00

abstract：:The "Woody" or "Wooden" breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher. Although of significant ethical and economic impact, little is known regarding the structural and funct...

journal_title：Frontiers in physiology

authors： Liu J,Puolanne E,Schwartzkopf M,Arner A

更新日期：2020-04-09 00:00:00

abstract：:Sleep inertia, the transitional state of reduced alertness and impaired cognitive performance upon waking, is a safety risk for on-call personnel who can be required to perform critical tasks soon after waking. Sleep inertia countermeasures have previously been investigated; however, none have successfully dissipated ...

journal_title：Frontiers in physiology

authors： Kovac K,Ferguson SA,Paterson JL,Aisbett B,Hilditch CJ,Reynolds AC,Vincent GE

更新日期：2020-04-07 00:00:00

abstract：:Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy more women on their missions; animal models rarely include females studies or comparisons between males and females. Therefore, we exposed adult female rats to 2...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-04-03 00:00:00

abstract：:The earliest humans relied on large quantities of metabolic energy from the oxidation of fatty acids to develop larger brains and bodies, prevent and reduce disease risk, extend longevity, in addition to other benefits. This was enabled through the consumption of a high fat and low-carbohydrate diet (LCD). Increased f...

journal_title：Frontiers in physiology

authors： Maffetone P,Laursen PB

更新日期：2020-04-02 00:00:00

abstract：:The term myocardial contractility is thought to have originated more than 125 years ago and has remained and enigma ever since. Although the term is frequently used in textbooks, editorials and contemporary manuscripts its definition remains illusive often being conflated with cardiac performance or inotropy. The abse...

journal_title：Frontiers in physiology

authors： Muir WW,Hamlin RL

更新日期：2020-03-31 00:00:00

abstract：:The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Huntington's. Glaucomatous optic neuropathy - the world's le...

journal_title：Frontiers in physiology

authors： McGrady NR,Risner ML,Vest V,Calkins DJ

更新日期：2020-03-26 00:00:00

abstract：:Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are re...

journal_title：Frontiers in physiology

authors： Cheng H,Lu T,Wang J,Xia Y,Chai X,Zhang M,Yao Y,Zhou N,Zhou S,Chen X,Su W,Liu C,Yi W,Chen Y,Yao L

更新日期：2020-03-25 00:00:00

abstract：:Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes. Among these channels, TRPML1 is a reactive oxygen species sensor localized on the lysosomal membran...

journal_title：Frontiers in physiology

authors： Santoni G,Maggi F,Amantini C,Marinelli O,Nabissi M,Morelli MB

更新日期：2020-03-24 00:00:00

abstract：:Defining variations in skeletal muscle passive mechanical properties at different size scales ranging from single muscle fibers to whole muscles is required in order to understand passive muscle function. It is also of interest from a muscle structural point-of-view to identify the source(s) of passive tension that fu...

journal_title：Frontiers in physiology

authors： Ward SR,Winters TM,O'Connor SM,Lieber RL

更新日期：2020-03-20 00:00:00

abstract：:Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial ...

journal_title：Frontiers in physiology

authors： Ang R,Marina N

更新日期：2020-03-18 00:00:00

abstract：:Lepidopteran species detect CO2 via a specialized organ located on the peripheral segment of the labial palps, the labial palp pit organ (LPO). Based on tracing of LPO sensory neurons targeting one distinct antennal-lobe glomerulus, Kent and her colleagues described the projections originating from the LPO in the sphi...

journal_title：Frontiers in physiology

authors： Kc P,Chu X,Kvello P,Zhao XC,Wang GR,Berg BG

更新日期：2020-03-17 00:00:00

abstract：Introduction:Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors. Methods:We analyzed beat-to-beat measurements of hemo...

journal_title：Frontiers in physiology

authors： Staats R,Barros I,Fernandes D,Grencho D,Reis C,Matos F,Valença J,Marôco J,de Almeida AB,Bárbara C

更新日期：2020-03-13 00:00:00

abstract：:Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal mode...

journal_title：Frontiers in physiology

authors： Scaramuzzo G,Ball L,Pino F,Ricci L,Larsson A,Guérin C,Pelosi P,Perchiazzi G

更新日期：2020-03-12 00:00:00

abstract：:The purpose of this systematic review was to investigate the scientific evidence to support the use of direct renin inhibitors (DRIs) in diabetic nephropathy (DN). MEDLINE was searched for articles reported until 2018. A standardized dataset was extracted from articles describing the effects of DRIs on plasma renin ac...

journal_title：Frontiers in physiology

authors： Massolini BD,Contieri SSG,Lazarini GS,Bellacosa PA,Dobre M,Petroianu G,Brateanu A,Campos LA,Baltatu OC

更新日期：2020-03-12 00:00:00

abstract：:Obesity is a worldwide epidemic disease that induces important structural and functional changes to the heart and predisposes a patient to devastating cardiac complications. Sirtuin1 (SIRT1) has been found to have roles in regulating cardiac function, but whether it can help in cardioprotection is not clear. The aim o...

journal_title：Frontiers in physiology

authors： Favero G,Franco C,Stacchiotti A,Rodella LF,Rezzani R

更新日期：2020-03-11 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a "disease of the sarcomere." Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms responsible for the deve...

journal_title：Frontiers in physiology

authors： Chowdhury SAK,Warren CM,Simon JN,Ryba DM,Batra A,Varga P,Kranias EG,Tardiff JC,Solaro RJ,Wolska BM

更新日期：2020-03-10 00:00:00

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in Arabidopsis and then in Drosophila and mice. They are evolutionarily conserved and play fundamental roles in the circadian clock of living organisms, enabling them to adapt to the daily 24-h cycles. The role of CRYs in circadi...

journal_title：Frontiers in physiology

authors： Damulewicz M,Mazzotta GM

更新日期：2020-03-05 00:00:00

abstract：:The pre-occlusal eruption brings the molars into functional occlusion and initiates tensional strains during mastication. We hypothesized that upon establishment of occlusal contact, the periodontal ligament (PDL) undergoes cell and extracellular matrix maturation to adapt to this mechanical function. The PDL of 12 Wi...

journal_title：Frontiers in physiology

authors： Denes BJ,Ait-Lounis A,Wehrle-Haller B,Kiliaridis S

更新日期：2020-03-05 00:00:00